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Platinum Priority – Prostate Cancer
Editorial by Benedikta S. Haflidadóttir and Yvonne Ceder on pp. 42–43 of this issue

Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer

By: Xiaoyi Huang a b , Tiezheng Yuan a , Meihua Liang c , Meijun Du a , Shu Xia a d , Rachel Dittmar a , Dian Wang e , William See f , Brian A. Costello g , Fernando Quevedo g , Winston Tan h , Debashis Nandy g , Graham H. Bevan i , Sherri Longenbach g , Zhifu Sun j , Yan Lu k , Tao Wang l , Stephen N. Thibodeau m , Lisa Boardman g , Manish Kohli g lowast and Liang Wang a lowast

European Urology, Volume 67 Issue 1, January 2015, Pages 33-41

Published online: 01 January 2015

Keywords: Exosome, microRNA, Extracellular RNA, RNA sequencing, Prostate cancer, Biomarker, Prognosis, Survival

Abstract Full Text Full Text PDF (2,6 MB) Patient Summary

Patient Summary In this study, we evaluated whether small RNAs circulating in blood could be used to predict clinical outcomes in late-stage prostate cancer patients. We identified two blood-based small RNAs whose levels showed significant association with survival. Our results warrant further investigation because the noninvasive blood-based test has great potential in the management of late-stage prostate cancer.

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