Journal Article Page
European UrologyVolume 58, issue 2, pages e19-e28, August 2010
Case Study of the Month
Neoadjuvant Temsirolimus Effectiveness in Downstaging Advanced Non–Clear Cell Renal Cell Carcinoma
Accepted 3 March 2010, Published online 12 March 2010, pages 307 - 310
A 35-year-old woman presented with a 12-cm right renal mass with retroperitoneal lymph node involvement and pulmonary and bone metastases. Renal mass biopsy revealed an unclassified high-grade non–clear cell renal cell carcinoma (RCC) with eosinophilic cells. Due to the extent of the disease, neoadjuvant temsirolimus was initiated. After 6 wk of treatment, a significant downstaging of the disease and complete disappearance of the metastases were noticed on computed tomography scan. Three months later, a laparoscopic radical nephrectomy and lymphadenectomy was performed. Final pathology confirmed a high-grade non–clear cell RCC, with necrotic changes on lymph node specimens, pT1bN0Mx.
Keywords: Temsirolimus, Non–clear cell renal cell carcinoma, Neoadjuvant.
© 2010 European Association of Urology, Published by Elsevier B.V.
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